One of the main programmes of University Hospital is studying the aetiopathogenesis of AAAs. The group from the Department of Surgery and Histopatology has been interested in the evaluation of cytokines, MMPs, vasoactive and inflammatory factors in the wall of AAAs for a long time and has longstanding (more then 15 years) experience in this field. The research involves both clinical and experimental (large animals) studies. Recently the new field of proteomics is being developed. About 60 AAAs and 10 TAAs are operated on or solved by EVAR yearly in our Department of Surgery.

Facilities description Patient recruitment, collection of plasma and tissue samples, storage of tissues (banks -80°C),animal facilities, enzymoimmunoanalysis, immunohistochemistry, proteomic technologies.

Tasks in FAD:

Clinical – endograft follow–up – AAA and TAA, biological samples of AAA wall, plasma of patients Pathophysiology of AAA- study of inflammation in AAAs walls

Members of the FAD staff Treska V (MD,PhD), vascular surgeon, experimental activities, WP1,WP4 Molacek J (MD,PhD), vascular surgeon, experimental activities, WP1,WP4 Kocova Jitka (MD,PhD), histopathologist, WP3 Tonar Zbynek (MD), histopathologist, WP3 Ondrej Hes (MD,PhD), histopathologist, WP3

Main publication/patent linked to FAD tasks

 Třeška V., Topolčan O.: Plasma and tissue levels of collagen type I and III markers in patients with abdominal aortic aneurysms. (Int Angiol Vol 19, No 1, 2000, 64-68)
 Třeška V., Valenta J.,Topolčan O., Pecen L.: Endogenous fibrinolysis in patients with lower extremity ischemia.(Ann Vasc Surg Vol. 14, No. 4, 2 000, 356-359
 Třeška V., Topolčan O., Pecen L.: Cytokines as Plasma Markers of Abdominal Aortic Aneurysm. (Clin Chem Lab Med 2 000, 38(11): 1161-1164
 Třeška V.,Molaček J., Topolčan O., Kočová J.: Plasma Cytokines Levels are Markers of Abdominal Aortic Aneurysm Development. (J Cardiovascular Surgery Suppl.,9/2001,75-76)
 Z.Tonar, S.Nemeček, R.Holota,J.Kočová, V.Třeška, J.Moláček, T.Kohoutek, S.Hadravská: Microscopic image analysis of elastin network in samples of normal, atherosclerotic and aneurysmatic abdominal aorta and its biomechanical implications. (J of Applied Biomedicine, Vol 1, No3, 2003,149-160)
 Třeška V., Kočová J., Topolčan O., Boudová L.: Inflammation in the wall of abdominal aneurysm and its role for symptomatology of aneurysm.(Cytokines, Cellular and Molecular Therapy Journal, Vol.7,No 3, 2002, 91-97) Moláček J, Třeška V, Kobr J, Certík B, Skalický T, Kuntscher V, Křížková V. Optimization of the Model of Abdominal Aortic Aneurysm - Experiment in an Animal Model. J Vasc Res. 2008 May 31;46(1):1-5.