In order to respond to the translational objective of the call, one of the initial tasks of the FAD consortium, will be to implement already existing, and develop new, clinical and biological human databases in aortic aneurysms.

These clinical databases will include screening for AAA in male populations over 65years of age (Denmark) and in patients presenting atherothrombosis in other localizations, and follow-up of small aneurysms, of patients treated by endograft, and of informative TAA families. These clinical databases will include current clinical investigations (physical examination, ultrasonography, clinical context, associated pathologies, familial history, etc), but also blood sampling for DNA, plasma and circulating cell banks. Clinical database will be diversified, in part specific of each raised questions, associating already constituted and in progress registries, biobank and trials, joined through a nested network. These databases will be organized as a web-based database using intranet private computer connectivity within the consortium to securely share FAD informations available in the different partner centers.

Therefore, these clinical databases will be associated with biological databases including: DNA libraries (families and cohorts), plasma samples (initial and follow-up), tissue samples (including pathological and normal vascular tissues), and cell samples (primary cultures from each patient suffering from monogenic disease; human smooth muscle cells, skin fibroblasts, macrophages, polymorphonuclear leukocytes, platelets, etc, isolation and culture, from undiseased and ecode mal tissues).