The INSERM units n° 698, 744, 712 covers the different aspects of the FAD project. This partner,n°1 has longstanding (over 15 years) experience and knowledge in aneurysmal pathology, including the discovery and development of various animal models, the demonstration of the involvement of mural thrombus biology in AAA progression & the study of new genes in TAA. Members of this INSERM group possess expertise in human vascular tissue and cell biology, immunohistochemistry & morphology, biochemistry of proteases, differential proteomics, genetics, clinical investigation, and animal models.
Different facilities, including patient recruitment, human vascular tissue and cell collections, animal facilities, proteomic technologies, including molecular imaging, different microscopic analytic tools, FACscanner, human cell culture laboratory, experimental and clinical MRI & scintigraphy, are available in the Inserm units or in its close proximity.
Tasks in FAD:
TAA and AAA clinical and biological database;Tissue & cell biology of the link between genetic polymorphism and phenotypic monomorphism in TAA; human genetics, functional genomics in mice, Specific roles of mucoid degeneration in TAA/ and of thrombus and adventitial inflammation in AAA; Diagnostic applications to biomarkers and functional imaging; Experimental therapeutic applications.
Members of the FAD staff
Michel JB (PhD, MD), CV surgeon, tissue & cell biology, pathology & animal models, FAD coordinator
Pinet F (PhD), vascular biologist, proteomics and cell biology,
Jeunemaitre Xavier (MD, PhD), cardiology and human genetics,
Jondeau G (MD, PhD), cardiologist, clinical & genetic databases in TAA,
Meilhac O (PhD) vascular biologist, proteomics & cell biology,
Le Guludec D (MD, PhD) nuclear medicine, functional imaging,
Letourneur D (PhD), chemist, polymers for biomaterials,
Jandrot-Perrus M (PhD, MD), biochemistry, hemostasis,
Perdu Jérôme (MD), internal medicine, clinical & genetic databases in TAA,
Hadchouel Juliette (Vet, PhD), molecular biologist, transgenic mice,
VonWill Sandrine (Ingenior), molecular biologist, genetic screening,
Beaurain Geneviève (PhD), molecular biologist, genetic screening.
Main publication linked to FAD tasks
Zhu L, Vranckx R, Van Kien PK, Lalande A, Gasc JM, Brunotte F, Bruneval P, Wolf JE, Michel JB, Jeunemaitre X. Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus. Nat Genet. 2006 Mar;38(3):343-349.
Sarda-Mantel L, Coutard M, Rouzet F, Raguin O, Vrigneaud JM, Hervatin F, Martet G, Touat Z, Merlet P, Le Guludec D, Michel JB. 99mTc-Annexin-V Functional Imaging of Luminal Thrombus Activity in Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol. 2006 Sep; 26(9):2153-9.
Touat Z, Ollivier V, Dai J, Huisse MG, Bezeaud A, Sebbag U, Palombi T, Rossignol P, Meilhac O, Guillin MC, Michel JB. Renewal of mural thrombus releases plasma markers and is involved in aortic abdominal aneurysm evolution. Am J Pathol. 2006 Mar;168(3):1022-30.
Dupont A, Corseaux D, Dekeyzer O, Drobecq H, Guihot AL, Susen S, Vincentelli A, Amouyel P, Jude B and Pinet F. (2005) The proteome and secretome of human arterial smooth muscle cell. Proteomics 5 : 585-596.
Slomianny MC, Dupont A, Bouanou F, Dekeyzer O, Guihot AL, Amouyel P, Michalski JC and Pinet F (2006) Profiling of membrane-proteins from human macrophages. Comparison of two approaches. Proteomics 6:2365-2375.
Dupont A, Pinet F. The proteome and secretome of human arterial smooth muscle cell.
Methods Mol Biol. 2007;357:225-33.
- Perdu J, Boutouyrie P, Bourgain C, Stern N, Laloux B, Bozec E, Azizi M, Bonaiti C, Plouin PF, Laurent S, Gimenez-Roqueplo AP, Jeunemaitre X. Inheritance of arterial lesions in fibromuscular dysplasia. J Hum Hypertens 2007 Mar 1; [Epub ahead of print]
Delaloy C, Hadchouel J, Imbert-Teboul M, Clemessy M, Houot AM, Jeunemaitre X. Cardiovascular Expression of the Mouse WNK1 Gene during Development and Adulthood Revealed by a BAC Reporter Assay. Am J Path 2006, Jul;169(1):105-18
Khau Van Kien P, Zhu LM, Mathieu F, Lalande A, Brunotte F, Wegman M, Glancy L, Betard C, Bruneval P, Lathrop GM, Wolf JE, Jeunemaitre X. Mapping of familial thoracic aortic aneurysm /dissection with patent ductus arteriosus to 16p12.2-p13.3. Circulation. 2005 ;112(2):200-207
Rossignol P, Cambillau M, Bissery A, Mouradian D, Benetos A, Michel JB, Plouin PF, Chatellier G, Jacob MP. Influence of blood sampling procedure on plasma concentrations of matrix metalloproteinases and their tissue inhibitors. Clin Exp Pharmacol Physiol. 2008 Apr;35(4):464-9.
Touat Z, Lepage L, Ollivier V, Nataf P, Hvass U, Labreuche J, Jandrot-Perrus M, Michel JB, Jondeau G. Dilation-Dependent Activation of Platelets and Prothrombin in Human Thoracic Ascending Aortic Aneurysm. Arterioscler Thromb Vasc Biol. 2008 May;28(5):940-6.
de Figueiredo Borges L, Jaldin RG, Dias RR, Stolf NA, Michel JB, Gutierrez PS. Collagen is reduced and disrupted in human aneurysms and dissections of ascending aorta. Hum Pathol. 2008 Mar;39(3):437-43.
Houard X, Rouzet F, Touat Z, Philippe M, Dominguez M, Fontaine V, Sarda-Mantel L, Meulemans A, Le Guludec D, Meilhac O, Michel JB. Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms. J Pathol. 2007; 212: 20-28.