The Vascular Research Unit (partner 8) covers different aspects of the FAD project. The Vascular Research Unit has since 1994 conducted a screening trial and explored the epidemiology, pathology, natural history and treatment of AAA. The Vascular Research Unit share expertises in epidemiology, management of large scale data from nation wide registries, databases, mass screening, statistics, ultrasonography, human vascular tissue, immunohistochemistry, proteomics, various types of serological assays, clinical investigations- and trials.
Different facilities, including patient recruitment, portable ultrasonography, human vascular tissue, plasma and cell collections at -80°C, LC-MS/MS proteomic technologies, flowcytometry, different equipment for set up of serological analyses including ELISA are available in the Vascular Unit or in its near environment.
Tasks in FAD:
Standardised AAA clinical and biological databases. Merging of various nation-wide registries and population based identification of familiar cases of AAA. Validation of prognostic value and diagnostic application of biomarkers and functional imaging; Retrospective analysis of already collected data, dealing with know medications
Members of the FAD staff
Jes Lindholt (MD, Ph.D). Epidemiology, screening, databases, biobanking,
functional imaging, biomarkers, proteomics, clinical trials
Eskild Henneberg (MD). Epidemiology, screening, databases, clinical trials,
administration
Nikolaj Grøndal (MD, Ph.D. Student). Epidemiology, screening, databases,
clinical trials
Winnie B. Lorentzen. Secretary. Administration and databases
Ass. Prof. Søren P. Johnsen (MD, Ph.D). Epidemiologist. Epidemiology. Large
scale data handling
Prof. Henrik T. Sørensen (MD, DMSc. Epidemiologist. Epidemiology. Large
scale data handling
Prof. Jan Sørensen (Ph.D.). Health Technology Assessment, Health economist
Sigitas Urbonavicius (MD, Ph.D). 2D electrophoretic-based proteomics
Prof. Bent Honoré (MD, DMSc). 2D electrophoretic-based and seldi-tof
proteomics, tissue and cell biology
Grazina Urbonavicienne (MD, Ph.D student). Ph.D. student. Serological
assays
Ass. Prof. Jan Frystyk (DMSc, Ph.D). Physician. Serological assays, tissue
& cell biology
Prof. Allan Flyvbjerg (DMSc, Ph.D). Physician. Serological assays, tissue &
cell biology
Anne Mette Saugmann. Nurse. Screening, follow up and biobanking.
Helle Mogensen. Nurse. Screening, follow up and biobanking.
Janni Lauridsen. Nurse. Screening, follow up and biobanking.
Heidi Kristensen. Nurse. Screening, follow up and biobanking.
Sidsel Ø. Nissen. Screening, follow up and biobanking.
Birgitte Vejsbæk. Nurse. Screening, follow up and biobanking.
Main publication/patent linked to FAD tasks
Lindholt JS. Relatively high pulmonary and cardiovascular mortality rates in screening-detected aneurysmal patients without previous hospital admissions. Eur J Vasc Endovasc Surg. 2007, 33:94-9.
Lindholt JS. Activators of plasminogen and the progression of small abdominal aortic aneurysms. Ann N Y Acad Sci. 2006 Nov;1085:139-50.
Lindholt JS, Shi GP. Chronic inflammation, immune response, and infection in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 2006 May;31(5):453-63.
Lindholt JS, Juul S, Fasting H, Henneberg EW. Screening for abdominal aortic aneurysms: single centre randomised controlled trial. BMJ. 2005 Apr 2;330(7494):750.
Urbonavicius S, Urbonaviciene G, Honoré B, Henneberg EW, Vorum H, Lindholt JS. Potential circulating biomarkers for abdominal aortic aneurysm expansion and rupture—a systematic review. Eur J Vasc Endovasc Surg. 2008 Sep;36(3):273-80;
Lindholt JS, Norman P. Screening for abdominal aortic aneurysm reduces overall mortality in men. A meta-analysis of the mid- and long-term effects of screening for abdominal aortic aneurysms.Eur J Vasc Endovasc Surg. 2008 Aug;36(2):167-71.
Lindholt JS. Aneurysmal wall calcification predicts natural history of small abdominal aortic aneurysms. Atherosclerosis. 2008 Apr;197(2):673-8.
Lindholt JS, Sørensen HT, Michel JB, Thomsen HF, Henneberg.EW. Low-dose aspirin may prevent growth and later surgical repair of medium-sized abdominal aortic aneurysms. Vasc. Endovasc. Surg. 2008; 42: 329-334.
